(2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran

Base Information

Chemical Name:(2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran
CAS No.:454474-90-9
Molecular Formula:C₄₈H₆₄O₇Si₂
Molecular Weight:809.203
Hs Code.:

Synonyms:(2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran

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Chemical Property of (2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran

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Technology Process of (2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran

There total 3 articles about (2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 92886-86-7
tert-butyldiphenylsilyl triflate

: 454474-64-7
(2R,3S,4S,5R)-3,4-dihydroxy-2,5-di-(1-pivaloyloxymethyl)tetrahydrofuran

: 454474-90-9
(2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; toluene; at 20 ℃; for 6h;
DOI:10.1021/jo020211h

Reference yield:

: 3282-30-2
pivaloyl chloride

: 454474-90-9
(2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / pyridine / 19 h / 0 - 20 °C

2: 93 percent / 2,6-lutidine / CH₂Cl₂; toluene / 6 h / 20 °C

With pyridine; 2,6-dimethylpyridine; In dichloromethane; toluene;
DOI:10.1021/jo020211h

Reference yield:

: 41107-82-8
2,5-anhydro-D-mannitol

: 454474-90-9
(2R,3R,4R,5R)-3,4-di-tert-butyldiphenylsilyloxy-2,5-di-(1-pivaloyloxymetyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / pyridine / 19 h / 0 - 20 °C

2: 93 percent / 2,6-lutidine / CH₂Cl₂; toluene / 6 h / 20 °C

With pyridine; 2,6-dimethylpyridine; In dichloromethane; toluene;
DOI:10.1021/jo020211h