2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

Base Information

Chemical Name:2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid
CAS No.:1580504-69-3
Molecular Formula:C₂₂H₂₂N₂O₅
Molecular Weight:394.427
Hs Code.:

Synonyms:2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

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Chemical Property of 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

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Technology Process of 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

There total 4 articles about 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1580504-68-2
methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

: 1580504-69-3
2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ml4004815

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1580504-69-3
2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol / 0.75 h / 120 °C / Inert atmosphere

3.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

3.2: 2.17 h / 0 - 120 °C / Inert atmosphere

4.1: lithium hydroxide / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; potassium carbonate; caesium carbonate; lithium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/ml4004815

Reference yield:

: 1580504-67-1
(5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methanol

: 1580504-69-3
2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

1.2: 2.17 h / 0 - 120 °C / Inert atmosphere

2.1: lithium hydroxide / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere

With sodium hydride; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/ml4004815