methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

Base Information

Chemical Name:methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate
CAS No.:1580504-68-2
Molecular Formula:C₂₃H₂₄N₂O₅
Molecular Weight:408.454
Hs Code.:

Synonyms:methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

Suppliers and Price of methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

There total 3 articles about methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 40134-18-7
methyl 2-chloropyridine-3-carboxylate

: 1580504-67-1
(5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methanol

: 1580504-68-2
methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

Guidance literature:: (5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methanol; With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

methyl 2-chloropyridine-3-carboxylate; In N,N-dimethyl-formamide; paraffin oil; at 0 - 120 ℃; for 2.16667h; Inert atmosphere;
DOI:10.1021/ml4004815

Reference yield:

: 947410-56-2
1-bromo-4-(2-methoxyethoxy)-2-methylbenzene

: 1580504-68-2
methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol / 0.75 h / 120 °C / Inert atmosphere

2.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2.17 h / 0 - 120 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; caesium carbonate; In methanol; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/ml4004815

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1580504-68-2
methyl 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol / 0.75 h / 120 °C / Inert atmosphere

3.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

3.2: 2.17 h / 0 - 120 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; potassium carbonate; caesium carbonate; In methanol; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/ml4004815