2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide

Base Information

Chemical Name:2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide
CAS No.:1580504-59-1
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide

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Chemical Property of 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide

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Technology Process of 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide

There total 5 articles about 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1580504-69-3
2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid

: 74-89-5
methylamine

: 1580504-59-1
2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide

Guidance literature:: 2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)nicotinic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

methylamine; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ml4004815

Reference yield:

: 947410-56-2
1-bromo-4-(2-methoxyethoxy)-2-methylbenzene

: 1580504-59-1
2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol / 0.75 h / 120 °C / Inert atmosphere

2.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2.17 h / 0 - 120 °C / Inert atmosphere

3.1: lithium hydroxide / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/ml4004815

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1580504-59-1
2-((5-(4-(2-methoxyethoxy)-2-methylphenyl)pyridin-2-yl)methoxy)-N-methylnicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol / 0.75 h / 120 °C / Inert atmosphere

3.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

3.2: 2.17 h / 0 - 120 °C / Inert atmosphere

4.1: lithium hydroxide / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/ml4004815