5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

Base Information

Chemical Name:5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester
CAS No.:141887-88-9
Molecular Formula:C₃₃H₄₉N₃O₄Si
Molecular Weight:579.855
Hs Code.:

5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

Synonyms:5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

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Chemical Property of 5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

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Technology Process of 5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

There total 13 articles about 5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 140900-69-2
19-(3-azidophenyl)-15-dehydro-20-norisocarbacyclin methyl ester

: 141887-88-9
5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

Guidance literature:: With 1H-imidazole; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88526-4

Reference yield:

: 92356-69-9
methyl (2E,4E)-5-(3-nitrophenyl)-2,4-pentadienoate

: 141887-88-9
5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 5percent Pd/C / methanol; benzene / 25 °C

2: 62 percent / pyridine / Ambient temperature

3: 1) n-BuLi / 1) THF, hexane, -78 deg C, 2) -78 deg C

4: AcOH, H₂O / tetrahydrofuran

5: 1) NaNO₂, AcOH, 2) NaN₃ / 1) THF, H₂O, 0 deg C, 2) 0 deg C

6: 1) NaH / 1) DME, toluene, oil, r.t., 2) DME, toluene

7: 77 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; 1H-imidazole; n-butyllithium; sodium azide; water; hydrogen; sodium hydride; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)88526-4

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 141887-88-9
5-[(3aS,5R,6R,6aS)-6-[(E)-7-(3-Azido-phenyl)-3-oxo-hept-1-enyl]-5-(tert-butyl-dimethyl-silanyloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1) LiN3)3>2 / 1) THF, -78 deg C, 2 h, 2) THF, a) -45 deg C, 10 min, b) 23 deg C, 18 h

2: H₂ / 5percent Pd/C / methanol; benzene / 25 °C

3: 62 percent / pyridine / Ambient temperature

4: 1) n-BuLi / 1) THF, hexane, -78 deg C, 2) -78 deg C

5: AcOH, H₂O / tetrahydrofuran

6: 1) NaNO₂, AcOH, 2) NaN₃ / 1) THF, H₂O, 0 deg C, 2) 0 deg C

7: 1) NaH / 1) DME, toluene, oil, r.t., 2) DME, toluene

8: 77 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; 1H-imidazole; n-butyllithium; sodium azide; water; hydrogen; sodium hydride; acetic acid; lithium hexamethyldisilazane; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)88526-4