di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

Base Information

Chemical Name:di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate
CAS No.:1616373-92-2
Molecular Formula:C₃₆H₅₃N₂O₇P
Molecular Weight:656.8
Hs Code.:

Synonyms:di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

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Chemical Property of di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

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Technology Process of di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

There total 7 articles about di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1062100-85-9
4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene

: bis(3-phenylpropyl) hydrophosphonate

: 1616373-92-2
di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.04.082

Reference yield:

: 122-97-4
3-Phenyl-1-propanol

: 1616373-92-2
di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus trichloride

2: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; phosphorus trichloride; In toluene;
DOI:10.1016/j.ejmech.2014.04.082

Reference yield:

: 196618-13-0
oseltamivir

: 1616373-92-2
di(3-phenylprop-1-yl) (3R,4R,5S)-4-acetamido-5-tert-butoxycarbonylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 2 h / 25 °C

2.1: potassium hydroxide / methanol; water / 2 h / 25 °C

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dmap / dichloromethane / 0.5 h / 25 °C

3.2: 3 h / 25 °C

4.1: 1,1,2-trifluoro-1-iodoethane / dichloromethane / 0.5 h / 25 °C / Photolysis

5.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / 90 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,1,2-trifluoro-1-iodoethane; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1016/j.ejmech.2014.04.082