4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene

Base Information

• Chemical Name: 4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene
• CAS No.: 1062100-85-9
• Molecular Formula: C₁₈H₃₁IN₂O₄
• Molecular Weight: 466.36
• Mol file: 1062100-85-9.mol

Synonyms:4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene

Chemical Property of 4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene

There total 8 articles about 4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

C23H35N3O5S2 → 4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene (1062100-85-9)

Guidance literature:

With 1,1,1-trifluoro-2-iodoethane; In dichloromethane; at 20 ℃; for 0.5h; Irradiation;

DOI:10.1016/j.ejmech.2018.12.027

Reference yield:

(3R,4R,5S)-4-acetamido-5-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropoxy)-1-bromocyclohexene (1062100-84-8) → 4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene (1062100-85-9)

Guidance literature:

With copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine; In butan-1-ol; at 120 ℃; for 24h;

DOI:10.1002/anie.200801959

Reference yield:

C23H35N3O6S2 (1373702-86-3) → 4-acetamido-5-(tert-butoxycarbonyl)amino-3-(1-ethylpropoxy)-1-iodo-1-cyclohexene (1062100-85-9)

Guidance literature:

With 1,1,2-trifluoro-1-iodoethane; In dichloromethane; at 25 ℃; for 0.5h; Photolysis;

DOI:10.1016/j.ejmech.2014.04.082

upstream raw materials:

(3R,4R,5S)-4-acetamido-5-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropoxy)-1-bromocyclohexene

oseltamivir

(3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

(3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

C₁₅H₂₉N₂O₅P

C₁₉H₃₇N₂O₅P

C₁₆H₃₁N₄O₅P