{1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine

Base Information

• Chemical Name: {1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine
• CAS No.: 882029-29-0
• Molecular Formula: C₁₇H₁₈FN₅O₂
• Molecular Weight: 343.361

Synonyms:{1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine

Chemical Property of {1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine

Chemical Property:

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Technology Process of {1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine

There total 2 articles about {1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

dimethoxyacetaldehyde (51673-84-8) + 1-fluoro-2-isocyanobenzene (77897-04-2) + aniline (62-53-3) → {1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine (882029-29-0)

Guidance literature:

With trimethylsilylazide; In methanol; for 48h;

DOI:10.1016/j.tetlet.2006.01.027

Reference yield:

N-(2-fluorophenyl)formamide (824-48-6) → {1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine (882029-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: POCl₃; NEt₃ / CH₂Cl₂ / 1 h / 20 °C

1.2: 2.52 g / Na₂CO₃ / CH₂Cl₂; H₂O

2.1: 58 percent / azidotrimethylsilane / methanol / 48 h

With trimethylsilylazide; triethylamine; trichlorophosphate; In methanol; dichloromethane; 2.1: Ugi reaction;

DOI:10.1016/j.tetlet.2006.01.027

Reference yield: 95.0%

{1-[1-(2-fluoro-phenyl)-1H-tetrazol-5-yl]-2,2-dimethoxy-ethyl}-phenyl-amine (882029-29-0) → 4-dimethoxymethyl-5-phenyl-4,5-dihydro-1,2,3,5,9b-pentaaza-cyclopenta[a]naphthalene

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 3h;

DOI:10.1016/j.tetlet.2006.01.027

upstream raw materials:

dimethoxyacetaldehyde

1-fluoro-2-isocyanobenzene

aniline

N-(2-fluorophenyl)formamide

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