(1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

Base Information

Chemical Name:(1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol
CAS No.:1361089-76-0
Molecular Formula:C₂₈H₃₄O₃Si
Molecular Weight:446.662
Hs Code.:

Synonyms:(1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

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Chemical Property of (1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

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Technology Process of (1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

There total 2 articles about (1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 100-52-7
benzaldehyde

: 185990-03-8
dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

: 337367-49-4
1-[(E)-buta-1,3-dienyl]-4-(methoxymethoxy-methyl)benzene

: 1361089-76-0
(1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

Guidance literature:: benzaldehyde; dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane; 1-[(E)-buta-1,3-dienyl]-4-(methoxymethoxy-methyl)benzene; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; C₆₀H₄₆NO₂P; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

With ammonium chloride; In water; N,N-dimethyl-formamide; at 0 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201107360

Reference yield:

: 100-52-7
benzaldehyde

: 185990-03-8
dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

: 337367-49-4
1-[(E)-buta-1,3-dienyl]-4-(methoxymethoxy-methyl)benzene

: (1R,3S,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

: 1361089-76-0
(1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

Guidance literature:: benzaldehyde; dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane; 1-[(E)-buta-1,3-dienyl]-4-(methoxymethoxy-methyl)benzene; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; C₃₄H₂₆NO₂P; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With ammonium chloride; In water; N,N-dimethyl-formamide; at 0 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201107360

Reference yield:

: 1361089-76-0
(1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol

: C₁₈H₂₄O₂Si

Guidance literature:: (1S,3R,4E)-3-dimethylphenylsilyl-5-(4-methoxymethoxymethylphenyl)-1-phenylpent-4-en-1-ol; With ozone; In methanol; at -78 ℃; for 0.25h;

With oxygen; In methanol; at -78 ℃; for 0.0833333h;

With sodium tetrahydroborate; In methanol; at -78 - 20 ℃;
DOI:10.1002/anie.201107360