1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole

Base Information

Chemical Name:1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole
CAS No.:1463609-42-8
Molecular Formula:C₂₃H₂₃ClN₂O
Molecular Weight:378.901
Hs Code.:

Synonyms:1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole

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Chemical Property of 1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole

Chemical Property:

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Technology Process of 1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole

There total 3 articles about 1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₄ClNO₂

: 1463609-42-8
1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole

: 1463609-43-9
2H-1-aza-2-oxa-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[1,2-c]isoxazole

Guidance literature:: With hydroxylamine hydrochloride; acetic acid; In ethanol; at 80 ℃; for 8h;
DOI:10.3390/molecules18078147

Reference yield:

: 807315-42-0
1-phenethyl-piperidine-4-carboxylic acid

: 1463609-42-8
1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole

: 1463609-43-9
2H-1-aza-2-oxa-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 40 °C

2: sodium hydride / mineral oil / 4 h / Reflux

3: hydroxylamine hydrochloride; acetic acid / ethanol / 8 h / 80 °C

With dmap; hydroxylamine hydrochloride; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; mineral oil;
DOI:10.3390/molecules18078147

Reference yield:

: 42348-86-7
5-chloro-1-indanone

: 1463609-41-7
phenyl 1-phenethylpiperidine-4-carboxylate

: 1463609-42-8
1H-1-oxa-2-aza-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[2,1-d]isoxazole

: 1463609-43-9
2H-1-aza-2-oxa-6-chloro-3-(1-phenethylpiperidin-4-yl)-1,4dihydroindeno[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / mineral oil / 4 h / Reflux

2: hydroxylamine hydrochloride; acetic acid / ethanol / 8 h / 80 °C

With hydroxylamine hydrochloride; sodium hydride; acetic acid; In ethanol; mineral oil;
DOI:10.3390/molecules18078147