Technology Process of Benzoic acid, 4-(cyclopropylamino)-, ethyl ester (9CI)
There total 6 articles about Benzoic acid, 4-(cyclopropylamino)-, ethyl ester (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; sodium tert-pentoxide;
In
toluene;
at 80 ℃;
for 18h;
Inert atmosphere;
DOI:10.1021/jacs.7b13087
- Guidance literature:
-
With
copper(l) iodide; potassium carbonate; L-proline;
In
dimethyl sulfoxide;
at 80 ℃;
for 5h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaNO2; HBF4 / H2O / 1.5 h / 0 - 20 °C
1.2: 80 percent / CH2Cl2 / 25 °C
2.1: tetrahydrofuran / 1 h / -20 °C
2.2: tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 3 h / 20 °C
3.1: Zn; AcOH; CF3CO2H / 0.25 h / 75 °C
With
tetrafluoroboric acid; acetic acid; trifluoroacetic acid; zinc; sodium nitrite;
In
tetrahydrofuran; water;
DOI:10.1002/anie.200353241
