N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

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Chemical Name:N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide
CAS No.:1123580-84-6
Molecular Formula:C₂₄H₂₀N₄O₂S
Molecular Weight:428.514
Hs Code.:

Synonyms:N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

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Chemical Property of N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

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Technology Process of N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

There total 6 articles about N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1123580-82-4
N-[3-(4-aminophenoxy)phenyl]-3-(1-cyano-1-methylethyl)benzamide

: 333-20-0
potassium thioacyanate

: 1123580-84-6
N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: N-[3-(4-aminophenoxy)phenyl]-3-(1-cyano-1-methylethyl)benzamide; potassium thioacyanate; With acetic acid; at 20 ℃; for 0.25h;

With bromine; acetic acid; at 20 ℃;

With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1123580-84-6
N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 150 °C

2.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 14 h / 20 °C

4.1: acetic acid / 0.25 h / 20 °C

4.2: 4.5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x

Reference yield:

: 872091-85-5
methyl 3-(1-cyano-1-methylethyl)benzoate

: 1123580-84-6
N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 18 h / 20 °C

2.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 4 - 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 14 h / 20 °C

5.1: acetic acid / 0.25 h / 20 °C

5.2: 4.5 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x