2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

Base Information

Chemical Name:2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one
CAS No.:1137869-51-2
Molecular Formula:C₁₄H₁₇ClF₂N₄O
Molecular Weight:330.765
Hs Code.:

Synonyms:2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

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Chemical Property of 2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

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Technology Process of 2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

There total 3 articles about 2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.9%

: 1137869-50-1
2-chloro-9-cyclohexyl-7,7-difluoro-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

: 74-88-4
methyl iodide

: 1137869-51-2
2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

Guidance literature:: With sodium hydride; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 1h;

Reference yield:

: 1137869-48-7
3-cyclohexylamino-2,2-difluoropropionic acid ethyl ester

: 1137869-51-2
2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethyl acetate / 18 h / 0 - 20 °C

2: iron; acetic acid / 2 h / 80 °C

3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With iron; sodium hydrogencarbonate; caesium carbonate; acetic acid; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.052

Reference yield:

: 1137869-49-8
3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

: 1137869-51-2
2-chloro-9-cyclohexyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: iron; acetic acid / 2 h / 80 °C

2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With iron; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.052