3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

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Chemical Name:3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester
CAS No.:1137869-49-8
Molecular Formula:C₁₅H₁₉ClF₂N₄O₄
Molecular Weight:392.79
Hs Code.:

Synonyms:3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

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Chemical Property of 3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

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Technology Process of 3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

There total 1 articles about 3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1137869-48-7
3-cyclohexylamino-2,2-difluoropropionic acid ethyl ester

: 49845-33-2
2,4-Dichloro-5-nitropyrimidine

: 1137869-49-8
3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate; at 0 - 20 ℃;

Reference yield:

: 1137869-49-8
3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

: 1137869-50-1
2-chloro-9-cyclohexyl-7,7-difluoro-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one

Guidance literature:: With iron; acetic acid; at 80 ℃; for 2h;

Reference yield:

: 1137869-49-8
3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2,2-difluoro-propionic acid ethyl ester

: 1137867-68-5
4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: iron; acetic acid / 2 h / 80 °C

2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: hydrogenchloride / ethanol; water / 18 h / Reflux

4: O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; iron; O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.052