4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride

Base Information

• Chemical Name: 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride
• CAS No.: 1027942-72-8
• Molecular Formula: C₁₆H₁₄ClF₂NO₄S
• Molecular Weight: 389.807
• Mol file: 1027942-72-8.mol

Synonyms:4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride

Chemical Property of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride

There total 7 articles about 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluorophenol (367-27-1) → 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride (1027942-72-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / KOH / 2 h / 120 °C

2: 83 percent / NaH / 1,2-dimethoxy-ethane / 1 h / 60 °C

3: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 2550.2 Torr / Ambient temperature

4: 89 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

5: 86 percent / NaOH / ethanol; H₂O / 2 h / Heating

6: oxalyl chloride, DMF / CH₂Cl₂ / 1 h / 0 deg C, 30 min, r.t. 30 min

With pyridine; potassium hydroxide; sodium hydroxide; oxalyl dichloride; hydrogen; sodium hydride; N,N-dimethyl-formamide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1055/s-1995-4129

Reference yield:

4-(2,4-difluorophenoxy)-3-nitrobenzaldehyde (173282-22-9) → 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride (1027942-72-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / NaH / 1,2-dimethoxy-ethane / 1 h / 60 °C

2: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 2550.2 Torr / Ambient temperature

3: 89 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 86 percent / NaOH / ethanol; H₂O / 2 h / Heating

5: oxalyl chloride, DMF / CH₂Cl₂ / 1 h / 0 deg C, 30 min, r.t. 30 min

With pyridine; sodium hydroxide; oxalyl dichloride; hydrogen; sodium hydride; N,N-dimethyl-formamide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1055/s-1995-4129

Reference yield:

4-(2,4-difluorophenoxy)-3-nitrocinnamate → 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride (1027942-72-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 2550.2 Torr / Ambient temperature

2: 89 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: 86 percent / NaOH / ethanol; H₂O / 2 h / Heating

4: oxalyl chloride, DMF / CH₂Cl₂ / 1 h / 0 deg C, 30 min, r.t. 30 min

With pyridine; sodium hydroxide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1055/s-1995-4129

upstream raw materials:

4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid

2,4-difluorophenol

4-(2,4-difluorophenoxy)-3-nitrobenzaldehyde

ethyl 3-amino-4-(2,4-difluorophenoxy)phenylpropionate

Downstream raw materials:

flosulide