2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol

Base Information

Chemical Name:2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol
CAS No.:185424-63-9
Molecular Formula:C₂₂H₂₈N₂O₆
Molecular Weight:416.474
Hs Code.:

Synonyms:2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol

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Chemical Property of 2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol

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Technology Process of 2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol

There total 12 articles about 2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 185424-61-7
2-[2-amino-4-(benzyloxycarbonyl)aminophenyl]propane-1,3-diol

: 185424-63-9
2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol

Guidance literature:: With sodium carbonate; In tetrahydrofuran; at 20 ℃; for 336h;

Reference yield: 85.0%

: aminodiol

: 24424-99-5
di-tert-butyl dicarbonate

: 497-19-8
sodium carbonate

: 185424-63-9
2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol

Guidance literature:: In tetrahydrofuran; water;

Reference yield:

: 157160-99-1
4-Chloro-3-nitrobenzoic acid tert-butyl ester

: 185424-63-9
2-[4-(benzyloxycarbonyl)amino-2-(t-butyloxycarbonyl)aminophenyl]propane-1,3-diol

Guidance literature:: Multi-step reaction with 9 steps

1: NaH / dimethylsulfoxide / 4 h / 70 - 80 °C

2: HCOOH / 1.) 20 deg C, 15 h, 2.) 50 deg C, 7 h

3: SOCl₂, DMF / 1,2-dichloro-ethane / 1 h / Heating

4: aq. NaN₃ / acetone / 0.5 h / 0 °C

5: toluene / 0.67 h / Heating

6: toluene / 2 h / 20 °C

7: 61 percent / DIBALH / tetrahydrofuran; hexane / 1 h / -8 - 20 °C

8: 94 percent / H₂ / PtO₂ / ethanol / 0.83 h / 20 °C / 2585.7 Torr

9: 91 percent / aq. Na₂CO₃ / tetrahydrofuran / 336 h / 20 °C

With formic acid; thionyl chloride; sodium azide; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium carbonate; N,N-dimethyl-formamide; platinum(IV) oxide; In tetrahydrofuran; ethanol; hexane; dimethyl sulfoxide; 1,2-dichloro-ethane; acetone; toluene;