3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine

Base Information

Chemical Name:3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine
CAS No.:1450018-72-0
Molecular Formula:C₂HF₃O₂*C₂₀H₁₇N₅O
Molecular Weight:457.412
Hs Code.:

Synonyms:3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine

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Chemical Property of 3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine

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Technology Process of 3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine

There total 8 articles about 3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 405554-89-4
4-(5-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine

: 947249-19-6
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine

: 76-05-1
trifluoroacetic acid

: 1450018-72-0
3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine

Guidance literature:: 4-(5-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine; 3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; at 90 ℃; for 18h; Inert atmosphere;

With hydrogenchloride; In water; at 60 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 10201-71-5
3-methoxypyridin-2-amine

: 1450018-72-0
3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C

1.2: pH 8 / Cooling with ice

2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

3.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 18 h / 90 °C / Inert atmosphere

3.2: 2 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; bromine; potassium acetate; sodium carbonate; acetic acid; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; 3.1: |Suzuki Coupling;

Reference yield:

: 405554-88-3
4-(2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine

: 1450018-72-0
3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; bromine / dichloromethane / 16 h / 0 - 20 °C

2.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 18 h / 90 °C / Inert atmosphere

2.2: 2 h / 60 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane; 2.1: |Suzuki Coupling;