(rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide

Base Information

Chemical Name:(rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide
CAS No.:1415248-54-2
Molecular Formula:C₂₀H₂₀FN₅O₃S
Molecular Weight:429.475
Hs Code.:

Synonyms:(rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide

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Chemical Property of (rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide

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Technology Process of (rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide

There total 11 articles about (rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414943-88-6,1414943-91-1,1414943-94-4
(rac)-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine

: 75-36-5
acetyl chloride

: 1415248-54-2
(rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 50h;

Reference yield:

: 1414944-11-8
(rac)-1-[(methylsulfinyl)methyl]-3-nitrobenzene

: 1415248-54-2
(rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium oxide; [bis(acetoxy)iodo]benzene / dirhodium tetraacetate / dichloromethane / 16 h / 20 °C

2.1: potassium carbonate; methanol / 1 h / 20 °C

3.1: pyridine / 24 h / 20 °C

4.1: hydrogenchloride; titanium(III) chloride / water; tetrahydrofuran / 18 h / 20 °C

4.2: pH 8 / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; tetrahydrofuran / 3 h / -40 - 0 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 1.33 h / 100 °C / Inert atmosphere

7.1: sodium ethanolate / ethanol / 7 h / 60 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 50 h / 0 °C

With pyridine; hydrogenchloride; methanol; titanium(III) chloride; [bis(acetoxy)iodo]benzene; sodium ethanolate; magnesium oxide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dirhodium tetraacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 619-23-8
3-Nitrobenzyl chloride

: 1415248-54-2
(rac)-N-[(3-{[4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl]amino}benzyl)(methyl)oxido-λ6-sulfanylidene]acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: ethanol / 3 h / -15 - 20 °C

2.1: periodic acid / iron(III) chloride / acetonitrile / 20 °C

3.1: magnesium oxide; [bis(acetoxy)iodo]benzene / dirhodium tetraacetate / dichloromethane / 16 h / 20 °C

4.1: potassium carbonate; methanol / 1 h / 20 °C

5.1: pyridine / 24 h / 20 °C

6.1: hydrogenchloride; titanium(III) chloride / water; tetrahydrofuran / 18 h / 20 °C

6.2: pH 8 / Cooling with ice

7.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; tetrahydrofuran / 3 h / -40 - 0 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 1.33 h / 100 °C / Inert atmosphere

9.1: sodium ethanolate / ethanol / 7 h / 60 °C / Inert atmosphere

10.1: triethylamine / dichloromethane / 50 h / 0 °C

With pyridine; hydrogenchloride; methanol; titanium(III) chloride; [bis(acetoxy)iodo]benzene; sodium ethanolate; magnesium oxide; potassium carbonate; periodic acid; triethylamine; N-ethyl-N,N-diisopropylamine; iron(III) chloride; dirhodium tetraacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;