2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:444119-58-8
Molecular Formula:C₂₁H₂₅NO₅
Molecular Weight:371.433
Hs Code.:

Synonyms:2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Chemical Property of 2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

There total 6 articles about 2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 444119-99-7
2,3-dimethoxy-5-(4-methoxybenzyloxy)-benzoic acid

: 444119-58-8
2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With tetrachloromethane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In pyridine; acetonitrile; at 80 ℃; for 16h;
DOI:10.1002/1521-3765(20020415)8:8<1850::AID-CHEM1850>3.0.CO;2-Q

Reference yield:

: 2973-76-4
5-bromo-4-hydroxy-3-methoxybenzaldehyde

: 444119-58-8
2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

2: 70 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Heating

3: 89 percent / dimethylformamide / 12 h / Heating

4: 82 percent / K₂CO₃; n-Bu₄NI / dimethylformamide / 12 h / 80 °C

5: 98 percent / aq. LiOH / methanol / 72 h / Heating

6: 80 percent / PPh₃; (iPr)2NEt; CCl₄ / pyridine; acetonitrile / 16 h / 80 °C

With tetrachloromethane; lithium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2: Baeyer-Villiger oxidation;
DOI:10.1002/1521-3765(20020415)8:8<1850::AID-CHEM1850>3.0.CO;2-Q

Reference yield:

: 6948-30-7
5-bromoveratralaldehyde

: 444119-58-8
2-[2,3-dimethoxy-5-(4-methoxybenzyloxy)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Heating

2: 89 percent / dimethylformamide / 12 h / Heating

3: 82 percent / K₂CO₃; n-Bu₄NI / dimethylformamide / 12 h / 80 °C

4: 98 percent / aq. LiOH / methanol / 72 h / Heating

5: 80 percent / PPh₃; (iPr)2NEt; CCl₄ / pyridine; acetonitrile / 16 h / 80 °C

With tetrachloromethane; lithium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Baeyer-Villiger oxidation;
DOI:10.1002/1521-3765(20020415)8:8<1850::AID-CHEM1850>3.0.CO;2-Q