(1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester

Base Information

Chemical Name:(1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester
CAS No.:290342-21-1
Molecular Formula:C₂₂H₂₉NO₂
Molecular Weight:339.478
Hs Code.:

Synonyms:(1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester

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Chemical Property of (1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester

Chemical Property:

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Technology Process of (1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester

There total 3 articles about (1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 768-94-5
1-Adamantanamine

: 290341-74-1
methyl (+)-(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylate

: 290342-21-1
(1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 8h;
DOI:10.1016/S0968-0896(00)00072-9

Reference yield:

: (1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid chloride

: 290342-21-1
(1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / benzene / 5 h / 20 °C

2: NaHCO₃ / dimethylformamide / 8 h / 70 °C

With hydrogenchloride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0014-827X(01)01170-3

Reference yield:

: (1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

: 290342-21-1
(1R,2S)-2-(Adamantan-1-ylaminomethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / benzene / 5 h / Heating

2: HCl / benzene / 5 h / 20 °C

3: NaHCO₃ / dimethylformamide / 8 h / 70 °C

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0014-827X(01)01170-3