N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide

Base Information

• Chemical Name: N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide
• CAS No.: 1226788-48-2
• Molecular Formula: C₁₇H₁₄ClFN₂O₃
• Molecular Weight: 348.761

Synonyms:N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide

Chemical Property of N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide

Chemical Property:

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Technology Process of N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide

There total 2 articles about N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetate (1226789-23-6) + (1S,2R)-1-amino-2-indanol (7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8) → N1-(4-chloro-3-fluorophenyl)-N2-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide (1226788-48-2)

Guidance literature:

In ethanol; at 150 ℃; for 1h; sealed tube;

DOI:10.1021/jm300265j

Reference yield:

→ N1-(4-chloro-3-fluorophenyl)-N2-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide (1226788-48-2)

Guidance literature:

In 1,4-dioxane; for 72h; Inert atmosphere; Reflux;

Reference yield: 70.0%

N1-(4-chloro-3-fluorophenyl)-N2-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide (1226788-48-2) + p-toluenesulfonyl chloride (98-59-9) → (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate (1374035-63-8)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm300265j

upstream raw materials:

ethyl 2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetate

(1S,2R)-1-amino-2-indanol

Downstream raw materials:

N¹-((1S,2S)-2-azido-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)oxalamide

N¹-((1S,2S)-2-amino-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)oxalamide

amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

(1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate

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