3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Base Information

Chemical Name:3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
CAS No.:608538-68-7
Molecular Formula:C₂₅H₂₃ClN₂O
Molecular Weight:402.923
Hs Code.:

3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[<i>e</i>][1,4]diazepin-2-one

Synonyms:3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Chemical Property of 3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Technology Process of 3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

There total 1 articles about 3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 41029-44-1
isopropyl triflate

: 39200-49-2
(S)-3-benzyl-7-chloro-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 608538-68-7
3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: (S)-3-benzyl-7-chloro-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

isopropyl triflate; In tetrahydrofuran; at 0 ℃; for 0.166667h;
DOI:10.1021/ja0365781

Reference yield:

: 608538-68-7
3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 74-88-4
methyl iodide

: 3-benzyl-7-chloro-1-isopropyl-3-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: 3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; hexane; for 0.25h;

With n-butyllithium; In tetrahydrofuran; hexane; for 0.25h;

methyl iodide; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;
DOI:10.1021/ja0365781

Reference yield:

: 106-95-6
allyl bromide

: 608538-68-7
3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 3-allyl-3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 3-allyl-3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: 3-benzyl-7-chloro-1-isopropyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; hexane; for 0.25h;

With n-butyllithium; In tetrahydrofuran; hexane; for 0.25h;

allyl bromide; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Title compound not separated from byproducts;
DOI:10.1021/ja0365781