7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Base Information

Chemical Name:7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
CAS No.:1429500-16-2
Molecular Formula:C₁₅H₁₅ClN₂O₂
Molecular Weight:290.749
Hs Code.:

Synonyms:7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

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Chemical Property of 7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

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Technology Process of 7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

There total 4 articles about 7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1338681-43-8
[7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid

: 541-41-3
chloroformic acid ethyl ester

: 1429500-16-2
7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: [7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetic acid; chloroformic acid ethyl ester; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h;

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1429500-16-2
7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / water; dichloromethane

2: lithium hydroxide

3: N-ethyl-N,N-diisopropylamine; sodium hydrogencarbonate / tetrahydrofuran; ethyl acetate

With lithium hydroxide; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

: 1429500-38-8
ethyl [7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetate

: 1429500-16-2
7-(3-chlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide

2: N-ethyl-N,N-diisopropylamine; sodium hydrogencarbonate / tetrahydrofuran; ethyl acetate

With lithium hydroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate;