(1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine

Base Information

• Chemical Name: (1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine
• CAS No.: 568565-46-8
• Molecular Formula: C₂₂H₂₄NOP
• Molecular Weight: 349.412
• Mol file: 568565-46-8.mol

Synonyms:(1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine

Chemical Property of (1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine

There total 3 articles about (1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (1R)-N-diphenylphosphinoylmethyl-N-1-phenylethylamine (568565-48-0) → (1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine (568565-46-8)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In acetonitrile; at 20 ℃; for 2h; pH=3 - 4;

DOI:10.1016/S0957-4166(03)00175-7

Reference yield:

Diphenylphosphine oxide (4559-70-0) → (1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine (568565-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / toluene / 2 h / Heating

2: 85 percent / NaBH₃CN / H₂O; acetonitrile / 2 h / 20 °C

With sodium cyanoborohydride; In water; toluene; acetonitrile;

DOI:10.1039/b302168h

Reference yield:

1,3,5-tris<(R)-(+)-phenylethyl>hexahydrotriazine (170716-16-2) → (1R)-N-diphenylphosphinoylmethyl-N-methyl-N-1-phenylethylamine (568565-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / toluene / 2 h / Heating

2: 85 percent / NaBH₃CN / H₂O; acetonitrile / 2 h / 20 °C

With sodium cyanoborohydride; In water; toluene; acetonitrile;

DOI:10.1039/b302168h

upstream raw materials:

formaldehyd

(1R)-N-diphenylphosphinoylmethyl-N-1-phenylethylamine

Diphenylphosphine oxide

1,3,5-tris<(R)-(+)-phenylethyl>hexahydrotriazine

Downstream raw materials:

(1R)-N-[(2-(2-isopropoxy-3-methoxy)phenyl)-4'-isopropoxyphenyl]vinyl-N-methyl-N-1-phenylethylamine

[(E)-2-(4-Benzyloxy-2-[1,3]dioxan-2-yl-5-methoxy-phenyl)-2-(4-benzyloxy-phenyl)-vinyl]-methyl-((R)-1-phenyl-ethyl)-amine

(1R,2R)-N-[2-((2-isopropoxy-3-methoxy)phenyl)-4'-isopropoxyphenyl]ethyl-N-methyl-N-1-phenylethylamine

(1R,2S)-N-[2-((2-isopropoxy-3-methoxy)phenyl)-4'-isopropoxyphenyl]ethyl-N-methyl-N-1-phenylethylamine