ROXATIDINE OXALATE

Base Information

• Chemical Name: ROXATIDINE OXALATE
• CAS No.: 110925-92-3
• Molecular Formula: 0C₂H₂O₄*C₁₇H₂₆N₂O₃
• Molecular Weight: 351.423
• Mol file: 110925-92-3.mol

Synonyms:ROXATIDINE OXALATE;Roxtidine oxalate

Chemical Property of ROXATIDINE OXALATE

Chemical Property:

• PSA: 136.40000
• LogP: 1.03430
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Roxatidine Hemioxalate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The major metabolite of Roxatidine Acetate (R700870).

Technology Process of ROXATIDINE OXALATE

There total 6 articles about ROXATIDINE OXALATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.36%

glycolic Acid (79-14-1) + N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine (73278-98-5) + oxalic acid (144-62-7,97993-78-7) → 2C17H26N2O3*C2H2O4 (110925-92-3)

Guidance literature:

glycolic Acid; N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine; at 150 ℃; for 2h;

oxalic acid; In ethanol; for 1h; Reflux;

Reference yield: 66.4%

oxalic acid (144-62-7,97993-78-7) + 2-hydroxy-N-[3-[3-(piperidinomethyl)phenoxy]propyl] acetamide (78273-80-0) → roxatidine hemioxalate (110925-92-3)

Guidance literature:

In ethanol; for 1h; Reflux;

Reference yield:

3-Carboxyphenol (99-06-9) → 2C17H26N2O3*C2H2O4 (110925-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.33 h / 20 °C

3.1: sodium hydroxide / dimethyl sulfoxide / 4 h / 30 - 65 °C

4.1: 2 h / 150 °C

4.2: 1 h / Reflux

With lithium aluminium tetrahydride; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; toluene;

upstream raw materials:

oxalic acid

2-hydroxy-N-[3-[3-(piperidinomethyl)phenoxy]propyl] acetamide

glycolic Acid

N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine

Downstream raw materials:

2-hydroxy-N-[3-[3-(piperidinomethyl)phenoxy]propyl] acetamide

Gastralgin

Refernces

• 1、 -. "Novel preparation method of intermediate namely 3-(1-piperidine methyl)phenol of roxatidine acetate hydrochloride". Paragraph 0070-0073. . Retrieved 2018/04/02.