2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide

Base Information

Chemical Name:2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide
CAS No.:1375419-04-7
Molecular Formula:C₂₁H₁₅ClF₂N₂O₄S
Molecular Weight:464.877
Hs Code.:

Synonyms:2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide

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Chemical Property of 2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide

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Technology Process of 2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide

There total 7 articles about 2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-amine

: 79455-63-3
2-chloro-6-fluorobenzoyl chloride

: 1375419-04-7
2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 24036-52-0
6-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one

: 1375419-04-7
2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: pyridine / dichloromethane / 4 h / 20 °C

3: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

4: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dimethylsulfide borane complex; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 7693-52-9
4-bromo-2-nitrophenol

: 1375419-04-7
2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / Reflux

2: iron; acetic acid / 4 h / 60 °C

3: dimethylsulfide borane complex / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

4: pyridine / dichloromethane / 4 h / 20 °C

5: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

6: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dimethylsulfide borane complex; iron; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;