(R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

Base Information

Chemical Name:(R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide
CAS No.:1589473-98-2
Molecular Formula:C₁₆H₁₆ClF₂NO₃S
Molecular Weight:375.824
Hs Code.:

Synonyms:(R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

Suppliers and Price of (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

Chemical Property:

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Technology Process of (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

There total 7 articles about (R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1589473-83-5
(R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)benzenesulfonamide

: 75-03-6
ethyl iodide

: 1589473-98-2
(R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1002/ardp.201300283

Reference yield:

: 1589473-76-6
(R)-4-benzyl-3-(2-(3,5-difluorophenyl)acetyl)oxazolidin-2-one

: 1589473-98-2
(R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.17 h / -78 °C / Inert atmosphere

2.1: lithium borohydride; water / tetrahydrofuran / 24.5 h / 0 - 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

4.1: pyridine / dichloromethane / 0.25 h / 20 °C

4.2: 24 h

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; lithium borohydride; palladium 10% on activated carbon; water; hydrogen; potassium hexamethylsilazane; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.201300283

Reference yield:

: 105184-38-1
3,5-difluorophenyl acetic acid

: 1589473-98-2
(R)-4-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)-N-ethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pivaloyl chloride; triethylamine / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 - 0 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C / Inert atmosphere

3.1: lithium borohydride; water / tetrahydrofuran / 24.5 h / 0 - 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

5.1: pyridine / dichloromethane / 0.25 h / 20 °C

5.2: 24 h

6.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; lithium borohydride; palladium 10% on activated carbon; water; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.201300283