ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate

Base Information

• Chemical Name: ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate
• CAS No.: 60943-38-6
• Molecular Formula: C₁₂H₁₂O₅
• Molecular Weight: 236.224
• Mol file: 60943-38-6.mol

Synonyms:ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate

Chemical Property of ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate

There total 1 articles about ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-Hydroxyacetophenone (121-71-1) + oxalic acid diethyl ester (95-92-1) → ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate (60943-38-6)

Guidance literature:

oxalic acid diethyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.25h;

3-Hydroxyacetophenone; In tetrahydrofuran; for 0.333333h; Reflux;

DOI:10.1016/j.bmcl.2017.03.009

Reference yield: 47.0%

ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate (60943-38-6) + 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile (244768-32-9) → C23H18N4O5

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 110 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.03.009

Reference yield: 47.0%

ethyl 4-(m-hydroxyphenyl)-2,4-dioxobutyrate (60943-38-6) → C10H8O5

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2017.03.009

upstream raw materials:

3-Hydroxyacetophenone

oxalic acid diethyl ester