7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol

Base Information

Chemical Name:7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol
CAS No.:1307813-48-4
Molecular Formula:C₂₅H₂₁F₃N₂O₆
Molecular Weight:502.447
Hs Code.:

Synonyms:7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol

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Chemical Property of 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol

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Technology Process of 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol

There total 12 articles about 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1236188-83-2
3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride

: 1307813-39-3
4-(7-(2,2-dimethyl-1,3-dioxolan-4-yl)-2H-chromen-4-yl)-morpholine

: 1307813-48-4
7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol

Guidance literature:: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride; 4-(7-(2,2-dimethyl-1,3-dioxolan-4-yl)-2H-chromen-4-yl)-morpholine; With triethylamine; In acetonitrile; at 0 - 20 ℃; for 1.5h;

With hydroxylamine hydrochloride; sodium acetate; In water; acetonitrile; at 45 ℃; for 1h;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307813-48-4
7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

3.2: 20 °C

4.1: pyridine / dichloromethane / 20 °C

5.1: triethylamine / acetonitrile / 1.5 h / 0 - 20 °C

5.2: 1 h / 45 °C

With pyridine; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 76240-27-2
7-hydroxy-2,3-dihydro-4H-chromen-4-one

: 1307813-48-4
7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3a,4-dihydro-3H-chromeno-[4,3-c]isoxazol-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 2.58 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

4.1: (R)-10-camphorsulfonic acid / acetone / 20 °C

5.1: titanium tetrachloride / toluene / 0 - 20 °C

6.1: triethylamine / acetonitrile / 1.5 h / 0 - 20 °C

6.2: 1 h / 45 °C

With osmium(VIII) oxide; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R)-10-camphorsulfonic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; water; acetone; toluene; acetonitrile;