Technology Process of 5-(3-amino-2-hydroxy-phenyl)-furan-2-carboxylic acid hydrobromide
There total 6 articles about 5-(3-amino-2-hydroxy-phenyl)-furan-2-carboxylic acid hydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(3-amino-2-methoxyphenyl)furan-2-carboxylic acid;
With
boron tribromide;
In
dichloromethane;
at 20 ℃;
for 1h;
With
methanol;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 40 h / 70 °C
2.1: potassium acetate / tetrakis(triphenylphosphine) palladium(0) / etheroxalic acid dimethyl ether / 17 h / Reflux
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / Reflux
3.2: pH 3
4.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3.5 h / Reflux
5.1: boron tribromide / dichloromethane / 1 h / 20 °C
5.2: 1 h
With
ammonium formate; potassium acetate; boron tribromide; sodium carbonate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; etheroxalic acid dimethyl ether; water; ethyl acetate; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium acetate / tetrakis(triphenylphosphine) palladium(0) / etheroxalic acid dimethyl ether / 17 h / Reflux
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / Reflux
2.2: pH 3
3.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3.5 h / Reflux
4.1: boron tribromide / dichloromethane / 1 h / 20 °C
4.2: 1 h
With
ammonium formate; potassium acetate; boron tribromide; sodium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; etheroxalic acid dimethyl ether; water; ethyl acetate;
