3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile

Base Information

Chemical Name:3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile
CAS No.:1454907-88-0
Molecular Formula:C₁₈H₂₅FN₂O₂Sn
Molecular Weight:439.117
Hs Code.:

Synonyms:3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile

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Chemical Property of 3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile

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Technology Process of 3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile

There total 3 articles about 3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454907-87-9
3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile

: 661-69-8
hexamethyldistannane

: 1454907-88-0
3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 80 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1431551-88-0
(4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

: 1454907-88-0
3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 927689-70-1
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

: 1454907-88-0
3-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(trimethylstannyl)phenyl)oxazolidin-3-yl)-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 20 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;