3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile

Base Information

Chemical Name:3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile
CAS No.:1454907-87-9
Molecular Formula:C₁₅H₁₆FIN₂O₂
Molecular Weight:402.207
Hs Code.:

Synonyms:3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile

Chemical Property:

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Technology Process of 3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile

There total 2 articles about 3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431551-88-0
(4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

: 372-09-8
cyanoacetic acid

: 1454907-87-9
3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 927689-70-1
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol

: 1454907-87-9
3-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 20 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With triethylamine; HATU; In N,N-dimethyl-formamide;