(3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester

Base Information

Chemical Name:(3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester
CAS No.:1236324-40-5
Molecular Formula:C₃₅H₅₂N₄O₈
Molecular Weight:656.82
Hs Code.:

Synonyms:(3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester

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Chemical Property of (3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester

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Technology Process of (3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester

There total 10 articles about (3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1236324-42-7
1-tert-butyloxycarbonyl-1-(6-benzyloxycarbonylaminohexyl)-hydrazine

: 79069-52-6
N-Boc-L-aspartic aldehyde β-benzyl ester

: 1236324-40-5
(3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester

Guidance literature:: 1-tert-butyloxycarbonyl-1-(6-benzyloxycarbonylaminohexyl)-hydrazine; N-Boc-L-aspartic aldehyde β-benzyl ester; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃;

With sodium hydrogencarbonate; In methanol; water; Cooling with ice;

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 1236324-40-5
(3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 2.5 h / Reflux

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 3.5 h / -20 - 20 °C

4.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

4.2: Cooling with ice

With di-isopropyl azodicarboxylate; sodium cyanoborohydride; hydrazine hydrate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; toluene; 2.1: Mitsunobu reaction;

Reference yield:

: 4048-33-3
6-amino-1-hexanol

: 1236324-40-5
(3S)-4-[2-(6-benzyloxycarbonylaminohexyl)-2-tert-butoxycarbonylhydrazino]-3-tert-butoxycarbonylaminobutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / water; tetrahydrofuran / 2.75 h / 5 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 3.5 h / -20 - 20 °C

4.1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

4.2: Cooling with ice

With di-isopropyl azodicarboxylate; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; water; 2.1: Mitsunobu reaction;