[((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

Base Information

Chemical Name:[((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester
CAS No.:1027735-09-6
Molecular Formula:C₂₃H₂₈N₂O₆
Molecular Weight:428.485
Hs Code.:

Synonyms:[((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

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Chemical Property of [((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

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Technology Process of [((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

There total 1 articles about [((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1142-20-7
N-Cbz-Ala

: 60857-16-1
N-(4-methoxybenzyl)glycine ethyl ester

: 1027735-09-6
[((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0957-4166(97)00614-9

Reference yield:

: 1027735-09-6
[((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

: [((S)-2-Amino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 14h; under 1810.02 Torr;
DOI:10.1016/S0957-4166(97)00614-9

Reference yield:

: 1027735-09-6
[((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

: (1R,4S)-1-Acetyl-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / methanol / 14 h / 1810.02 Torr

2: methanol / 12 h / Heating

3: 1.) Et₃OBF₄, Na₂CO₃ / 1.) CH₂Cl₂, RT, overnight, 2.) 130-140 deg C, 2.5 h

4: 1.) KHMDS / 1.) THF, -78 deg C, 6 min, 2.) THF, from -78 to 0 deg C

With hydrogen; triethyloxonium fluoroborate; potassium hexamethylsilazane; sodium carbonate; palladium on activated charcoal; In methanol;
DOI:10.1016/S0957-4166(97)00614-9