(1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Base Information

Chemical Name:(1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione
CAS No.:204581-50-0
Molecular Formula:C₂₅H₂₇N₃O₄
Molecular Weight:433.507
Hs Code.:

Synonyms:(1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

There total 5 articles about (1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60857-16-1
N-(4-methoxybenzyl)glycine ethyl ester

: 204581-50-0
(1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / DCC / CH₂Cl₂

2: H₂ / 10percent Pd/C / methanol / 14 h / 1810.02 Torr

3: methanol / 12 h / Heating

4: 1.) Et₃OBF₄, Na₂CO₃ / 1.) CH₂Cl₂, RT, overnight, 2.) 130-140 deg C, 2.5 h

5: 1.) KHMDS / 1.) THF, -78 deg C, 6 min, 2.) THF, from -78 to 0 deg C

With hydrogen; triethyloxonium fluoroborate; potassium hexamethylsilazane; sodium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0957-4166(97)00614-9

Reference yield:

: 1027735-09-6
[((S)-2-Benzyloxycarbonylamino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

: 204581-50-0
(1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / methanol / 14 h / 1810.02 Torr

2: methanol / 12 h / Heating

3: 1.) Et₃OBF₄, Na₂CO₃ / 1.) CH₂Cl₂, RT, overnight, 2.) 130-140 deg C, 2.5 h

4: 1.) KHMDS / 1.) THF, -78 deg C, 6 min, 2.) THF, from -78 to 0 deg C

With hydrogen; triethyloxonium fluoroborate; potassium hexamethylsilazane; sodium carbonate; palladium on activated charcoal; In methanol;
DOI:10.1016/S0957-4166(97)00614-9

Reference yield:

: [((S)-2-Amino-propionyl)-(4-methoxy-benzyl)-amino]-acetic acid ethyl ester

: 204581-50-0
(1R,4S)-1-(2,2-Dimethyl-propionyl)-2-(4-methoxy-benzyl)-4-methyl-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 12 h / Heating

2: 1.) Et₃OBF₄, Na₂CO₃ / 1.) CH₂Cl₂, RT, overnight, 2.) 130-140 deg C, 2.5 h

3: 1.) KHMDS / 1.) THF, -78 deg C, 6 min, 2.) THF, from -78 to 0 deg C

With triethyloxonium fluoroborate; potassium hexamethylsilazane; sodium carbonate; In methanol;
DOI:10.1016/S0957-4166(97)00614-9