3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester

Base Information

Chemical Name:3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester
CAS No.:127130-81-8
Molecular Formula:C₂₈H₃₀N₂O₆
Molecular Weight:490.556
Hs Code.:

Synonyms:3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester

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Chemical Property of 3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester

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Technology Process of 3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester

There total 6 articles about 3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3143-02-0
3-hydroxymethyl-3-methyloxethane

: 127130-81-8
3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / (dimethylamino)pyridine, dicylohexylcarbodiimide / diethyl ether / 0.25 h / 25 °C

2: 84 percent / BF₃ / CH₂Cl₂; diethyl ether / 2 h / -4 °C

3: 96 percent / H₂ / Pd-C / ethanol / 7 h / 760 Torr / Ambient temperature

4: 88 percent / triethylamine / tetrahydrofuran / 11 h / 50 °C

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 10 min, 2.) 30 min

With dmap; n-butyllithium; boron trifluoride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00180a049

Reference yield:

: 127130-93-2
N-(benzyloxycarbonyl)-L-tryptophane (3-methyl-3-oxetanyl)methyl ester

: 127130-81-8
3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / BF₃ / CH₂Cl₂; diethyl ether / 2 h / -4 °C

2: 96 percent / H₂ / Pd-C / ethanol / 7 h / 760 Torr / Ambient temperature

3: 88 percent / triethylamine / tetrahydrofuran / 11 h / 50 °C

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 10 min, 2.) 30 min

With n-butyllithium; boron trifluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00180a049

Reference yield:

: 127130-94-3
[(S)-2-(1H-Indol-3-yl)-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester

: 127130-81-8
3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / H₂ / Pd-C / ethanol / 7 h / 760 Torr / Ambient temperature

2: 88 percent / triethylamine / tetrahydrofuran / 11 h / 50 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 10 min, 2.) 30 min

With n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/ja00180a049