methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

Base Information

Chemical Name:methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride
CAS No.:106787-89-7
Molecular Formula:C₁₈H₁₉NO₄*ClH
Molecular Weight:349.814
Hs Code.:

Synonyms:methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

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Chemical Property of methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

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Technology Process of methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

There total 6 articles about methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 106787-79-5
methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

: 106787-89-7
methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; In methanol; at -78 ℃; for 1h;
DOI:10.1248/cpb.34.1994

Reference yield:

: 40611-00-5
DL-3-(3,4-dihydroxyphenyl)alanine methyl ester hydrochloride

: 106787-89-7
methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / K₂CO₃ / diethyl ether; H₂O / 2 h / Ambient temperature

2: 83 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

3: 10 percent anhydrous HCl / methanol / 1 h / Ambient temperature

4: 65 percent / 4-nitrobenzyl bromide / acetonitrile / 72 h / Heating

5: 62 percent / 1.) NaBH₄, 2.) HCl / methanol / 1 h / -78 °C

With Lawessons reagent; hydrogenchloride; sodium tetrahydroborate; potassium carbonate; 1-bromomethyl-4-nitro-benzene; In methanol; 1,2-dimethoxyethane; diethyl ether; water; acetonitrile;
DOI:10.1248/cpb.34.1994

Reference yield:

: 106787-71-7
N-phenylmethylthiocarbonyl-3,4-dihydroxyphenylalanine methyl ester

: 106787-89-7
methyl cis-6,7-dihydro-1-phenylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / 4-nitrobenzyl bromide / acetonitrile / 72 h / Heating

2: 62 percent / 1.) NaBH₄, 2.) HCl / methanol / 1 h / -78 °C

With hydrogenchloride; sodium tetrahydroborate; 1-bromomethyl-4-nitro-benzene; In methanol; acetonitrile;
DOI:10.1248/cpb.34.1994