methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

Base Information

Chemical Name:methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide
CAS No.:106787-79-5
Molecular Formula:BrH*C₁₈H₁₇NO₄
Molecular Weight:392.249
Hs Code.:

Synonyms:methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

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Chemical Property of methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

Chemical Property:

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Technology Process of methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

There total 5 articles about methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 106787-71-7
N-phenylmethylthiocarbonyl-3,4-dihydroxyphenylalanine methyl ester

: 106787-79-5
methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

Guidance literature:: With 1-bromomethyl-4-nitro-benzene; In acetonitrile; for 72h; Heating;
DOI:10.1248/cpb.34.1994

Reference yield:

: 40611-00-5
DL-3-(3,4-dihydroxyphenyl)alanine methyl ester hydrochloride

: 106787-79-5
methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / K₂CO₃ / diethyl ether; H₂O / 2 h / Ambient temperature

2: 83 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

3: 10 percent anhydrous HCl / methanol / 1 h / Ambient temperature

4: 65 percent / 4-nitrobenzyl bromide / acetonitrile / 72 h / Heating

With Lawessons reagent; hydrogenchloride; potassium carbonate; 1-bromomethyl-4-nitro-benzene; In methanol; 1,2-dimethoxyethane; diethyl ether; water; acetonitrile;
DOI:10.1248/cpb.34.1994

Reference yield:

: 106787-85-3
3-(3,4-Bis-phenylacetoxy-phenyl)-2-phenylacetylamino-propionic acid methyl ester

: 106787-79-5
methyl 6,7-dihydroxy-1-phenylmethyl-3,4-dihydroisoquinoline-3-carboxylate hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

2: 10 percent anhydrous HCl / methanol / 1 h / Ambient temperature

3: 65 percent / 4-nitrobenzyl bromide / acetonitrile / 72 h / Heating

With Lawessons reagent; hydrogenchloride; 1-bromomethyl-4-nitro-benzene; In methanol; 1,2-dimethoxyethane; acetonitrile;
DOI:10.1248/cpb.34.1994