Technology Process of 1-cyclohexyl-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-h][1,6]naphthyridine
There total 10 articles about 1-cyclohexyl-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-h][1,6]naphthyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
3.1: butan-1-ol / 16 h / 110 °C
4.1: diisobutylaluminium hydride / toluene / 2 h / -78 - 20 °C
5.1: manganese(IV) oxide / chloroform / 16 h / 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C
7.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C
8.1: hydrogenchloride / ethanol; water / 2 h / 40 °C
8.2: 2 h / 0 °C
9.1: sodium hydroxide / water; 1,4-dioxane / 48 h / 100 °C
With
hydrogenchloride; manganese(IV) oxide; palladium 10% on activated carbon; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; toluene; butan-1-ol;
6.1: |Wittig Olefination;
DOI:10.1016/j.bmcl.2012.11.108
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sec.-butyllithium / tetrahydrofuran / 0.67 h / -78 - 20 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
4.1: butan-1-ol / 16 h / 110 °C
5.1: diisobutylaluminium hydride / toluene / 2 h / -78 - 20 °C
6.1: manganese(IV) oxide / chloroform / 16 h / 20 °C
7.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C
8.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C
9.1: hydrogenchloride / ethanol; water / 2 h / 40 °C
9.2: 2 h / 0 °C
10.1: sodium hydroxide / water; 1,4-dioxane / 48 h / 100 °C
With
hydrogenchloride; manganese(IV) oxide; palladium 10% on activated carbon; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sec.-butyllithium; sodium hydride; diisobutylaluminium hydride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; toluene; butan-1-ol;
7.1: |Wittig Olefination;
DOI:10.1016/j.bmcl.2012.11.108
