3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

Base Information

Chemical Name:3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate
CAS No.:117023-47-9
Molecular Formula:C₄H₄O₄*C₃₀H₃₃F₂NO₄
Molecular Weight:625.666
Hs Code.:

Synonyms:3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

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Chemical Property of 3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

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Technology Process of 3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

There total 5 articles about 3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 117022-45-4
3-(3-chloro-propoxy)-benzoic acid ethyl ester

: 117023-47-9
3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

Guidance literature:: With sodium carbonate; potassium iodide; 1) DMF, reflux;
DOI:10.1021/jm00121a022

Reference yield:

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 117022-45-4
3-(3-chloro-propoxy)-benzoic acid ethyl ester

: 117023-47-9
3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

Guidance literature:: With potassium iodide; sodium carbonate; In N-methyl-acetamide;

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-47-9
3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 67 percent / 1) Na₂CO₃, KI / 1) DMF, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022