6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone

Base Information

Chemical Name:6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone
CAS No.:78823-13-9
Molecular Formula:C₂₇H₂₄ClN₃O₄
Molecular Weight:489.958
Hs Code.:

6-Chloro-1-methyl-3-<methyl<N-(benzyloxycarbonyl)-glycyl>amino>-4-phenyl-2(1H)-quinolone

Synonyms:6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone

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Chemical Property of 6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone

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Technology Process of 6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone

There total 3 articles about 6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57180-64-0
2-(methylamino-acetamido)-5-chloro-benzophenone

: 78823-13-9
6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) SOCl₂ / 1) HMPA, -8 to -5 deg C, 15 min, 2) ethyl acetate, -5 deg C - RT, 5 h

2: 1) NaH / 1) THF, -5 to 0 deg C, 15 min, 2) 0 deg C - RT, then 1 h

With thionyl chloride; sodium hydride;
DOI:10.1021/jo00335a034

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 78823-13-9
6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) SOCl₂ / 1) HMPA, -8 to -5 deg C, 15 min, 2) ethyl acetate, -5 deg C - RT, 5 h

2: 1) NaH / 1) THF, -5 to 0 deg C, 15 min, 2) 0 deg C - RT, then 1 h

With thionyl chloride; sodium hydride;
DOI:10.1021/jo00335a034

Reference yield:

: 78823-08-2
2'-Benzoyl-4'-chloro-N-sarcosinanilide

: 74-88-4
methyl iodide

: 78823-13-9
6-Chloro-1-methyl-3-amino>-4-phenyl-2(1H)-quinolone

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1) THF, -5 to 0 deg C, 15 min, 2) 0 deg C - RT, then 1 h;
DOI:10.1021/jo00335a034