2,3-Dihydro-benzofuran-3-ylamine

Base Information

• Chemical Name: 2,3-Dihydro-benzofuran-3-ylamine
• CAS No.: 109926-35-4
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2932999099
• European Community (EC) Number: 895-466-2
• ChEMBL ID: CHEMBL4586207
• DSSTox Substance ID: DTXSID00911400
• Mol file: 109926-35-4.mol

Synonyms:109926-35-4;2,3-DIHYDRO-BENZOFURAN-3-YLAMINE;2,3-DIHYDROBENZOFURAN-3-AMINE;2,3-DIHYDRO-1-BENZOFURAN-3-AMINE;3-Amino-2,3-Dihydrobenzofuran;MFCD06738729;(R)-2,3-Dihydro-benzofuran-3-ylamine;(3S)-2,3-Dihydro-benzofuran-3-ylamine;3-BENZOFURANAMINE, 2,3-DIHYDRO-;SCHEMBL507362;CHEMBL4586207;2,3-Dihydrobenzofuran-3-ylamine;DTXSID00911400;PLCGAGSBVAGXMP-UHFFFAOYSA-N;AMY41792;AKOS000224036;AKOS016051200;rac-2,3-dihydro-benzofuran-3-ylamine;AB27757;SB32043;SB32048;BS-13245;SY283285;CS-0371944;EN300-78962;I11926

Chemical Property of 2,3-Dihydro-benzofuran-3-ylamine

Chemical Property:

• Vapor Pressure: 0.175mmHg at 25°C
• Refractive Index: 1.58
• Boiling Point: 212.239 °C at 760 mmHg
• PKA: 8.45±0.20(Predicted)
• Flash Point: 88.725 °C
• PSA: 35.25000
• Density: 1.154 g/cm³
• LogP: 1.77910
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.068413911
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

99% ^*data from raw suppliers

3-AMINO-2,3-DIHYDROBENZOFURAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C2=CC=CC=C2O1)N

Technology Process of 2,3-Dihydro-benzofuran-3-ylamine

There total 11 articles about 2,3-Dihydro-benzofuran-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzofuran-3(2H)-one oxime (82415-84-7) → dihydro-2,3 benzofurannamine-3 (109926-35-4,1228553-27-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 17h;

DOI:10.1016/j.tetlet.2012.09.030 DOI:10.1016/j.tetlet.2012.09.030

Reference yield: 38.0%

tert-butyl (2,3-dihydrobenzofuran-3-yl)carbamate (1410747-74-8) → dihydro-2,3 benzofurannamine-3 (109926-35-4,1228553-27-2)

Guidance literature:

With tetrachloromethane; boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.09.030 DOI:10.1016/j.tetlet.2012.09.030

Reference yield:

2-(2-(((benzyloxy)imino)methyl)phenoxy)acetic acid → 1-benzofurane (271-89-6) + dihydro-2,3 benzofurannamine-3 (109926-35-4,1228553-27-2) + C15H15NO2 (1542225-87-5) + benzaldehyde (100-52-7) + benzofuran-3(2H)-one O-benzyloxime + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With titanium(IV) oxide; In acetonitrile; for 24h; Inert atmosphere; Schlenk technique; UV-irradiation;

DOI:10.1021/jo4027929

upstream raw materials:

3(2H)-benzofuranone oxime

3-nitrobenzofuran

diethyl ether

3-oxo-2,3-dihydrobenzo[b]furan

Downstream raw materials:

tert-butyl benzyl(2,3-dihydrobenzofuran-3-yl)carbamate

methyl benzyl(2,3-dihydrobenzofuran-3-yl)carbamate

N-benzyl-2,3-dihydrobenzofuran-3-amine

rac-N-[2-(2,3-Dihydro-benzofuran-3-ylamino)-quinolin-5-yl]-3,4,5-trifluoro-benzenesulfonamide

Refernces

• 1、 -. "ERK INHIBITORS". Page/Page column 91. . Retrieved 2016/07/05.
• 2、 Chiba, Hiroaki,Sakai, Yuki,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki. "Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans and its application to the formal total synthesis of (-)-quinocarcinamide". supporting information. p. 6273 - 6276,4. Retrieved 2012/12/12.