4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline

Base Information

Chemical Name:4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline
CAS No.:1201788-08-0
Molecular Formula:C₂₈H₂₀FN₅O₂S
Molecular Weight:509.564
Hs Code.:

Synonyms:4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline

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Chemical Property of 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline

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Technology Process of 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline

There total 4 articles about 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201787-20-3
3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 1201788-08-0
4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 125 ℃; for 1h; Microwave irradiation; Sealed tube;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1201788-08-0
4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Sealed tube

With n-butyllithium; sodium hydride; caesium carbonate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide;

Reference yield:

: 1201786-84-6
3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201788-08-0
4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Sealed tube

With n-butyllithium; sodium hydride; caesium carbonate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide;