2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide

Base Information

• Chemical Name: 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide
• CAS No.: 245364-99-2
• Molecular Formula: C₂₂H₂₁FN₂O₄S
• Molecular Weight: 428.484
• Mol file: 245364-99-2.mol

Synonyms:2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide

Chemical Property of 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide

There total 4 articles about 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorobenzenesulfonyl chloride (349-88-2) → 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide (245364-99-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / pyridine

2: 96 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

3: TFA / CH₂Cl₂

4: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate (213015-69-1) → 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide (245364-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

2: TFA / CH₂Cl₂

3: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

[benzyl-(4-fluoro-benzenesulfonyl)-amino]-acetic acid tert-butyl ester (245364-70-9) → 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-acetamide (245364-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(99)00311-X

upstream raw materials:

O-benzylhydoxylamine hydrochloride

N-benzyl-N-[(4-fluorophenyl)sulfonyl]glycine

4-Fluorobenzenesulfonyl chloride

tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate