5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Base Information

Chemical Name:5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
CAS No.:911370-66-6
Molecular Formula:C₁₆H₁₇ClF₂N₆O
Molecular Weight:382.8
Hs Code.:

Synonyms:5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

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Chemical Property of 5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

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Technology Process of 5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

There total 10 articles about 5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 911370-61-1
5-chloro-1-(2,6-difluorophenyl)-7-(methylsulfinyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

: 108-00-9
N,N-dimethylethylenediamine

: 911370-66-6
5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 357935-93-4
4-Chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbonitrile

: 911370-66-6
5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 4 h / Heating / reflux

1.2: 0.5 h / 20 °C

1.3: pH 9.0 - 10.0

2.1: dichloromethane / 3 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

4.1: triethylamine / dichloromethane / 20 °C

With borane-THF; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 33097-11-9
4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde

: 911370-66-6
5-chloro-1-(2,6-difluorophenyl)-7-{[2-(dimethylamino)ethyl]amino}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride; acetic acid / ethanol / 2 h / 20 - 70 °C

2.1: thionyl chloride / 3 h / 20 - 75 °C

3.1: N,N-dimethyl-formamide / 1 h / 50 °C

4.1: borane-THF / tetrahydrofuran / 4 h / Heating / reflux

4.2: 0.5 h / 20 °C

4.3: pH 9.0 - 10.0

5.1: dichloromethane / 3 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

7.1: triethylamine / dichloromethane / 20 °C

With thionyl chloride; borane-THF; hydroxylamine hydrochloride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;