2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester

Base Information

• Chemical Name: 2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester
• CAS No.: 864166-08-5
• Molecular Formula: C₁₇H₁₆F₃NO₄
• Molecular Weight: 355.314
• Mol file: 864166-08-5.mol

Synonyms:2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester

Chemical Property of 2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester

There total 2 articles about 2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

propargyl bromide (106-96-7) + 2-benzyloxycarbonylamino-2-trifluoromethylbut-3-enoic acid methyl ester (129398-25-0) → 2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester (864166-08-5)

Guidance literature:

2-benzyloxycarbonylamino-2-trifluoromethylbut-3-enoic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201101209

Reference yield:

vinyl magnesium bromide (1826-67-1) + 2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester (128970-26-3) + propargyl bromide (106-96-7) → 2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester (864166-08-5)

Guidance literature:

vinyl magnesium bromide; 2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester;

propargyl bromide;

DOI:10.1021/ol051393f

Reference yield: 37.0%

2-(benzyloxycarbonyl-prop-2-ynyl-amino)-2-trifluoromethyl-but-3-enoic acid methyl ester (864166-08-5) + diazomethyl-trimethyl-silane (18107-18-1) → (1R,2S,5S)-2-Trifluoromethyl-5-((Z)-2-trimethylsilanyl-vinyl)-3-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester + (1S,2S,5R)-2-Trifluoromethyl-5-((Z)-2-trimethylsilanyl-vinyl)-3-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester

Guidance literature:

chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In diethyl ether; at 20 ℃; for 0.166667h;

DOI:10.1021/ol051393f

upstream raw materials:

vinyl magnesium bromide

2-benzyloxycarbonylimino-3,3,3-trifluoropropionic acid methyl ester

propargyl bromide

2-benzyloxycarbonylamino-2-trifluoromethylbut-3-enoic acid methyl ester