2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

Base Information

Chemical Name:2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester
CAS No.:102841-29-2
Molecular Formula:C₁₆H₂₀F₂N₂O₅
Molecular Weight:358.342
Hs Code.:

Synonyms:2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

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Chemical Property of 2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

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Technology Process of 2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

There total 8 articles about 2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102841-31-6
2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-difluoromethyl-pentanedioic acid dimethyl ester

: 102841-29-2
2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

Guidance literature:: With hydrogen bromide; In acetic acid;
DOI:10.1016/S0040-4020(01)86044-0

Reference yield:

: 95755-27-4,143730-59-0
DL-α-difluoromethylglutamic acid

: 102841-29-2
2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 24 h / Heating

2: triethylamine / 1,2-dimethoxy-ethane

3: HBr, acetic acid

With thionyl chloride; hydrogen bromide; acetic acid; triethylamine; In 1,2-dimethoxyethane;

Reference yield:

: 66891-86-9
benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate

: 102841-29-2
2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,2-dimethoxy-ethane

2: HBr, acetic acid

With hydrogen bromide; acetic acid; triethylamine; In 1,2-dimethoxyethane;