2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester

Base Information

• Chemical Name: 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester
• CAS No.: 102841-30-5
• Molecular Formula: C₂₃H₂₆F₂N₈O₅
• Molecular Weight: 532.507
• Mol file: 102841-30-5.mol

Synonyms:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester

Chemical Property of 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester

There total 10 articles about 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromomethyl-pteridine-2,4-diamine (59368-16-0) + 2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester (102841-29-2) → 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester (102841-30-5)

Guidance literature:

In N,N-dimethyl acetamide;

Reference yield:

DL-α-difluoromethylglutamic acid (95755-27-4,143730-59-0) → 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester (102841-30-5)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂ / 24 h / Heating

2: triethylamine / 1,2-dimethoxy-ethane

3: HBr, acetic acid

4: N,N-dimethyl-acetamide

With thionyl chloride; hydrogen bromide; acetic acid; triethylamine; In 1,2-dimethoxyethane; N,N-dimethyl acetamide;

Reference yield:

benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate (66891-86-9) → 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-difluoromethyl-pentanedioic acid dimethyl ester (102841-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 1,2-dimethoxy-ethane

2: HBr, acetic acid

3: N,N-dimethyl-acetamide

With hydrogen bromide; acetic acid; triethylamine; In 1,2-dimethoxyethane; N,N-dimethyl acetamide;

upstream raw materials:

6-bromomethyl-pteridine-2,4-diamine

2-Difluoromethyl-2-(4-methylamino-benzoylamino)-pentanedioic acid dimethyl ester

6-bromomethyl-2,4-diaminopteridine hydrobromide

DL-α-difluoromethylglutamic acid

Downstream raw materials:

N-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-2-difluoromethyl-glutamic acid