N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide

Base Information

• Chemical Name: N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide
• CAS No.: 1350515-54-6
• Molecular Formula: C₂₁H₁₈N₄O₃S
• Molecular Weight: 406.465

Synonyms:N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide

Chemical Property of N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide

Chemical Property:

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Technology Process of N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide

There total 4 articles about N₃-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

6-methoxybenzothiazol-2-ylamine (1747-60-0) + 2-((4-methoxyphenyl)amino)nicotinic acid (4394-09-6) → N3-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide (1350515-54-6)

Guidance literature:

2-((4-methoxyphenyl)amino)nicotinic acid; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

6-methoxybenzothiazol-2-ylamine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1016/j.bmc.2011.09.060

Reference yield:

4-methoxy-aniline (104-94-9) → N3-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide (1350515-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethylene glycol / 6 h / 160 °C

2.1: sodium hydroxide / ethanol / 2 h / Reflux

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; ethylene glycol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.09.060

Reference yield:

ethyl 2-((4-methoxyphenyl)amino)nicotinate (95774-49-5) → N3-[6-(methyloxy)-1,3-benzothiazol-2-yl]-2-[4-(methyloxy)phenyl]amino-3-pyridinecarboxamide (1350515-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 2 h / Reflux

2.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.09.060

upstream raw materials:

6-methoxybenzothiazol-2-ylamine

2-((4-methoxyphenyl)amino)nicotinic acid

4-methoxy-aniline

ethyl 2-chloronicotinate

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