Ethyl 2-(4-methoxyanilino)pyridine-3-carboxylate

Base Information

Chemical Name:Ethyl 2-(4-methoxyanilino)pyridine-3-carboxylate
CAS No.:95774-49-5
Molecular Formula:C15H16N2O3
Molecular Weight:272.304
Hs Code.:
DSSTox Substance ID:DTXSID10557590
Wikidata:Q82439543

Synonyms:95774-49-5;Ethyl 2-(4-methoxyanilino)pyridine-3-carboxylate;SCHEMBL10377167;DTXSID10557590;PJLBKNMTYQBAQA-UHFFFAOYSA-N;ethyl 2-(4-methoxyphenylamino)nicotinate

Suppliers and Price of Ethyl 2-(4-methoxyanilino)pyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-(4-methoxyanilino)pyridine-3-carboxylate

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:272.11609238
Heavy Atom Count:20
Complexity:304

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=CC=C1)NC2=CC=C(C=C2)OC

Technology Process of Ethyl 2-(4-methoxyanilino)pyridine-3-carboxylate

There total 2 articles about Ethyl 2-(4-methoxyanilino)pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 104-94-9
4-methoxy-aniline

: 1452-94-4
ethyl 2-chloronicotinate

: 95774-49-5
ethyl 2-((4-methoxyphenyl)amino)nicotinate

Guidance literature:: In ethylene glycol; at 140 ℃; for 8h;
DOI:10.1016/j.bmc.2014.11.001

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 95774-49-5
ethyl 2-((4-methoxyphenyl)amino)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂SO₄ / 3 h / Heating

2: 80 percent / ethane-1,2-diol / 6 h / 160 °C

With sulfuric acid; In ethylene glycol;
DOI:10.1016/j.bmc.2006.10.027

Reference yield: 100.0%

: 95774-49-5
ethyl 2-((4-methoxyphenyl)amino)nicotinate

: 4394-09-6
2-((4-methoxyphenyl)amino)nicotinic acid

Guidance literature:: ethyl 2-((4-methoxyphenyl)amino)nicotinate; With sodium hydroxide; In ethanol; for 2h; Reflux;

With hydrogenchloride; In ethanol; water;
DOI:10.1016/j.bmc.2011.09.060